Therapeutic targeting of AXL/Gas6 signaling in metastatic and primary cancer
Abstract/Contents
- Abstract
- AXL is a receptor tyrosine kinase shown to be involved in driving metastasis and disease progression in many of solid and hematologous human cancers. Our lab has previously shown that inhibiting the activation of AXL by trapping its only ligand, Gas6, can reduce metastatic disease burden in several aggressive cancer models. Using engineered high-affinity AXL decoy receptors, we show that inhibiting AXL downstream signaling by preventing the binding of Gas6 to native AXL receptors can halt disease progression in acute myeloid leukemia (AML). Collectively, these results validate AXL as a therapeutic target in metastatic disease and highlight the potential clinical value of the engineered AXL decoy receptors as novel anti-metastatic therapies. We further examine the validity of AXL as a therapeutic target in canine melanoma, an alternative model of melanoma that mirrors many of the features of human melanoma
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Diep, Anh Ngoc |
|---|---|
| Degree supervisor | Giaccia, Amato J |
| Thesis advisor | Giaccia, Amato J |
| Thesis advisor | Ford, James M. (James Matthew) |
| Thesis advisor | Graves, Edward (Edward Elliot), 1974- |
| Thesis advisor | Rankin, Erinn |
| Degree committee member | Ford, James M. (James Matthew) |
| Degree committee member | Graves, Edward (Edward Elliot), 1974- |
| Degree committee member | Rankin, Erinn |
| Associated with | Stanford University, Cancer Biology Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Anh Ngoc Diep |
|---|---|
| Note | Submitted to the Cancer Biology Program |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Anh Ngoc Diep
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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