Uses of adult and pluripotent stem cells for treatment of heart disease
Abstract/Contents
- Abstract
- Heart disease is the leading cause of morbidity and mortality in the developed world. Adult and pluripotent stem cells offer the potential to revolutionize medical treatment of cardiovascular disease through generation of patient and disease-specific cadiomyocytes heart tissue and blood vessels for the first time. However, translation of stem cell-based technologies to the patient bedside face a number of challenges including acute donor cell death, poor differentiation into therapeutic cell populations, and tumorigenicity. Here, we outline several of the major hurdles limiting cell therapy efficacy in patients suffering from heart disease as well as several applications of molecular imaging modalities to address these challenges. We furthermore describe several novel applications of stem cell platforms for modeling patient-specific heart disease and personalized drug screening. Finally, we describe the identification of a novel vessel forming adult stem cell population, which may have future applications in cell therapy for treatment of ischemic injury.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lee, Andrew |
|---|---|
| Associated with | Stanford University, Program in Chemical and Systems Biology. |
| Primary advisor | Wu, Joseph Ching-Ming, 1971- |
| Thesis advisor | Wu, Joseph Ching-Ming, 1971- |
| Thesis advisor | Calos, Michele P |
| Thesis advisor | Chen, James Kenneth |
| Thesis advisor | Longaker, Michael T |
| Thesis advisor | Wysocka, Joanna, Ph. D |
| Advisor | Calos, Michele P |
| Advisor | Chen, James Kenneth |
| Advisor | Longaker, Michael T |
| Advisor | Wysocka, Joanna, Ph. D |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Andrew Lee. |
|---|---|
| Note | Submitted to the Program in Chemical and Systems Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Andrew Stephen Lee
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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