Dynamic strategy for personalized medicine : an application to metastatic breast cancer
Abstract/Contents
- Abstract
- Planning for treatment of cancer is challenging due to the complexity of the disease. Oncologists have to select and switch therapies considering the trade-off between treatment efficacy and therapy sides effects for an increasing number of therapies and combinations. Moreover, cancer varies with different patient characteristics and past treatment history. We develop a framework for computing a dynamic strategy for therapy choice in a large class of breast cancer patients, as an example of approaches to personalize therapies for individual characteristics and each patient's response to therapy. Our model maintains a Markov belief about the effectiveness of the different therapies and updates it as therapies are administered and tumor images are observed. We compare three different approximate methods to solve our analytical model against standard medical practice and show significant potential benefit of the computed dynamic strategies to limit tumor growth and to reduce the number of time periods patients are given chemotherapy, with its attendant side effects. We test robustness of our model with sensitivity analysis on key model parameters, seeing how the optimal dynamic strategy changes when patient characteristics differ. We also demonstrate the scalability of our model and recommended algorithm, showing that it has potential of providing real time advice to patients and oncologists.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Chen, Xi |
|---|---|
| Associated with | Stanford University, Department of Management Science and Engineering. |
| Primary advisor | Shachter, Ross D |
| Thesis advisor | Shachter, Ross D |
| Thesis advisor | Howard, Ronald A. (Ronald Arthur), 1934- |
| Thesis advisor | Rubin, Daniel |
| Advisor | Howard, Ronald A. (Ronald Arthur), 1934- |
| Advisor | Rubin, Daniel |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Xi Chen. |
|---|---|
| Note | Submitted to the Department of Management Science and Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Xi Chen
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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