Electrostatic catalysis : a physical principle for designing faster enzymes
Abstract/Contents
- Abstract
- Enzymes are proficient biocatalysts arising from billions of years of evolution. Understanding the fundamental principles of how enzymes achieve such remarkable rate accelerations may facilitate the rational design of efficient artificial enzymes and small-molecule catalysts, which remains a grand challenge despite decades-long effort. Through extensive structural studies such as x-ray crystallography, it has been well recognized that a key to enzyme catalysis is a pre-organized active site, where the chemical transformation occurs; however, the energetic basis that links active-site structures to their catalytic power remains much debated, which, in part, impedes the progress of enzyme and catalyst design. Building upon the previous studies, this dissertation is focused on characterizing the unique electrostatic environment in an enzyme's active site and revealing its functional importance in enzyme catalysis. The results presented in this work suggest a general design principle of catalysts with a focus on the electric field, an underexplored element that is powerful for enhancing reaction rates.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Zheng, Chu |
|---|---|
| Degree supervisor | Boxer, Steven G. (Steven George), 1947- |
| Thesis advisor | Boxer, Steven G. (Steven George), 1947- |
| Thesis advisor | Fayer, Michael D |
| Thesis advisor | Stack, T. (T. Daniel P.), 1959- |
| Degree committee member | Fayer, Michael D |
| Degree committee member | Stack, T. (T. Daniel P.), 1959- |
| Associated with | Stanford University, School of Humanities and Sciences |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Chu Zheng. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/ky603gz6524 |
Access conditions
- Copyright
- © 2023 by Chu Zheng
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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