How mechanical properties of the pancreas signal the immune system in type 1 diabetes
Abstract/Contents
- Abstract
- Inflamed tissues experience a change in stiffness compared to their healthy state. This could be partially a result of accumulation of the glycosaminoglycan hyaluronan (HA). T cells can sense external mechanical forces, as seen in stiff and soft matrix. The goal of this work is to investigate the role of mechanobiology in type 1 diabetes (T1D) using HA-based hydrogels that mimic the physiological mechanics and biophysical cues in pancreatic islets.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | De la Zerda, Adi |
|---|---|
| Degree supervisor | Bollyky, Paul |
| Degree supervisor | Heilshorn, Sarah |
| Thesis advisor | Bollyky, Paul |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Melosh, Nicholas A |
| Degree committee member | Melosh, Nicholas A |
| Associated with | Stanford University, Department of Materials Science and Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Adi De la Zerda. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Adi De la Zerda
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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