Determining causal relationships between the microbiome and immune system
Abstract/Contents
- Abstract
- The gut microbiome is a diverse ecosystem of ~100 trillion microbes deeply embedded in multiple aspects of human immune and metabolic function. Defining the causal mechanisms underlying the gut-immune axis is imperative to understand dysregulation during disease and the correction necessary for therapeutic development. This work presents three different strategies to determine the language by which microbes communicate with our human physiology: 1) conduct interventional human studies to determine how microbiome-targeted interventions affect the immune profile, 2) characterize microbial and metabolic profiles indicative of a healthy and diseased state, and 3) identify circulating small molecules that are both are microbially derived and causal for immune modulation.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Wastyk, Hannah Constance |
|---|---|
| Degree supervisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Bendall, Sean, 1979- |
| Thesis advisor | Fischbach, Michael |
| Thesis advisor | Holmes, Susan, 1954- |
| Degree committee member | Bendall, Sean, 1979- |
| Degree committee member | Fischbach, Michael |
| Degree committee member | Holmes, Susan, 1954- |
| Associated with | Stanford University, Department of Bioengineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Hannah Constance Wastyk. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/kx924dc6930 |
Access conditions
- Copyright
- © 2021 by Hannah Constance Wastyk
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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