Towards a holistic language for engineering synthetic morphogenesis
Abstract/Contents
- Abstract
- Biological patterns form in a distributed manner through self-assembly and have the capacity to self-heal. The ability to engineer synthetic morphogenesis will advance our way of patterning. Here, I develop a language to facilitate the engineering of synthetic morphogenesis. This language is motivated by an exercise to design and grow a yinyang-like pattern from a single \textit{Escherichia coli} cell. The language consists of the abstraction and implementation of functions for engineering the curvature, texture, and reliability of cell lineage borders. These border functions are realized holistically, as an emergent consequence of cell physical properties such as growth rate and cell shape, as opposed to an explicit genetic system. I used the border functions to design and grow two-dimensional phases of the moon, pacmans with different size mouths, and a yinyang-like pattern. The holistic language facilitates the engineering of more complex synthetic morphogenesis than previously achieved and serves as a foundation for expanding our ability to engineer synthetic patterns.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Choksi, Atri Tushar |
|---|---|
| Associated with | Stanford University, Department of Bioengineering. |
| Primary advisor | Endy, Andrew D |
| Thesis advisor | Endy, Andrew D |
| Thesis advisor | Frank, C. W |
| Thesis advisor | Huang, Kerwyn Casey, 1979- |
| Thesis advisor | Riedel-Kruse, Hans |
| Advisor | Frank, C. W |
| Advisor | Huang, Kerwyn Casey, 1979- |
| Advisor | Riedel-Kruse, Hans |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Atri Tushar Choksi. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Atri Tushar Choksi
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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