Coronavirus emergence and plasmodium parasite prelude : unraveling first infections
Abstract/Contents
- Abstract
- This dissertation embarks on a comprehensive journey to explore and contrast the T cell responses to two distinct infectious diseases: COVID-19 and malaria. By delving into the immunological intricacies of these diseases, this research aims to shed light on the critical roles T cells play in the immune response to both a novel pandemic and an ancient endemic disease. The second chapter presents insights into the dynamics of CD4+ T cell responses following SARS-CoV-2 infection, highlighting a shift in cytokine production patterns and underscoring the potential role of TNF$\alpha$-producing CD4+ T cells in sustaining post-infection immunity. The third chapter focuses on malaria's impact on immune responses during pregnancy, particularly among primigravid women, revealing the modulation of immune responses by Type 1 regulatory (Tr1) cells. The fourth chapter explores genetic factors influencing malaria susceptibility through a study on Diversity Outbred mice, identifying specific loci associated with varying disease outcomes. This thesis integrates these findings to enhance our understanding of T cell correlates and genetic factors that shape immune responses during initial infections. By contrasting the historical context of malaria with the contemporary challenge of COVID-19, the research provides a unique perspective on the evolution of immune responses and their implications. This comprehensive study not only advances our knowledge of immunology but also proposes therapeutic insights, aiming to inform future targeted interventions in the fight against infectious diseases.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Kirosingh, Adam Setori |
|---|---|
| Degree supervisor | Jagannathan, Prasanna |
| Thesis advisor | Jagannathan, Prasanna |
| Thesis advisor | Schneider, David (David Samuel) |
| Thesis advisor | Wang, Taia |
| Degree committee member | Schneider, David (David Samuel) |
| Degree committee member | Wang, Taia |
| Associated with | Stanford University, School of Medicine |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Adam Kirosingh. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/kt254nv3204 |
Access conditions
- Copyright
- © 2023 by Adam Setori Kirosingh
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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