Understanding particle migration, margination and adhesion in cellular suspensions
Abstract/Contents
- Abstract
- In this thesis, we develop a theoretical framework for red blood cell migration, platelet margination and adhesion in pressure-driven channel flow based on the hydrodynamic principles of particles in Stokes flow and the kinetic information on platelet adhesion under arteriole flow conditions. We also perform simulation and experimental studies to verify our theoretical predictions. We identify deformability-induced lift force and shear-induced diffusion as governing mechanisms for the cross-flow transport of red blood cells. The absence of a lift force for rigid platelets is the key to their margination. We explore the steady state and non-equilibrium behaviors of particle migration and margination and consider the scenarios of rigidified red blood cells due to malaria infection and migration in small arterioles. We also investigate the effects of flow properties (e.g. shear rate) and platelet properties (e.g. receptor densities) on platelet adhesion. We elucidate the role of particle deformability in changing the microstructure of such suspensions in wall-bound channel flow. Therefore we emphasize the role of red blood cell volume fraction (hematocrit) on the rates of these three processes which ultimately lead to hemostasis and thrombosis.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Qi, Qin |
|---|---|
| Degree supervisor | Shaqfeh, Eric S. G. (Eric Stefan Garrido) |
| Thesis advisor | Shaqfeh, Eric S. G. (Eric Stefan Garrido) |
| Thesis advisor | Fuller, Gerald G |
| Thesis advisor | Qin, Jian, (Professor of Chemical Engineering) |
| Degree committee member | Fuller, Gerald G |
| Degree committee member | Qin, Jian, (Professor of Chemical Engineering) |
| Associated with | Stanford University, Department of Chemical Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Qin Qi. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Qin Qi
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...