Innate immune regulation of metabolic physiology & inflammatory rhythm
- Monophagocytes are a frontline defense against anything that should not be present in the body. Being highly mobile, they infiltrate almost every tissue to consume and dispose of material that might be damaging. To fight pathogens, monocytes and macrophages are transformed into pro-inflammatory machines that secrete catecholamines. However, monocytes and macrophages also exist in alternatively activated, anti-inflammatory forms that have a wide range of physiological roles. Unlike classically activated cells, which exhibit high pro-inflammatory potential, alternatively activated monocytes and macrophages (which are promoted by the TH2-type cytokines IL-4 and IL-13) are less pro-inflammatory and have distinct secretory and functional capacities. The inherent functional plasticity as well as the omnipresence of monocytes and macrophages in all tissues enables them to sense environmental changes. My dissertation will highlight two physiological settings in which, monocytes and macrophages, act as the sensors of perturbations in the environment to activate distinct physiological programs. The first part of my dissertation will discuss the role of adipose tissue alternatively activated macrophages in sensing changes in environmental temperature and its subsequent involvement in the maintenance of body temperature. The second part of my dissertation will provide evidences to show that inflammatory monocytes can sense change in the daily light dark cycle via their interaction with the circadian clock system to generate diurnal oscillation in monocyte-mediated inflammation.
|Innate immune regulation of metabolic physiology and inflammatory rhythm
|Type of resource
|electronic; electronic resource; remote
|1 online resource.
|Nguyen, Khoa Dinh
|Stanford University, Program in Immunology.
|Engleman, Edgar G
|Engleman, Edgar G
|Statement of responsibility
|Khoa Dinh Nguyen.
|Submitted to the Program in Immunology.
|Thesis (Ph.D.)--Stanford University, 2013.
- © 2013 by Khoa Dinh Nguyen
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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