Interspecies organogenesis
Abstract/Contents
- Abstract
- Advances in stem cell technology and tissue engineering promise clinical applications. Although much progress is being made, developing whole organs from in vitro cultured cells proves difficult. The spatial and temporal intricacies that occur during organogenesis ensure adequate perfusion, organ size, tissue distribution and function. Since many developmental properties are not cell intrinsic, proper development requires rapidly evolving extrinsic cues that may act locally or in gradients. This environment is difficult to model in vitro. To generate fully functional organs from patient-specific induced pluripotent stem cells (iPSCs), in vivo approaches have been attempted in which an animal is used as a bioreactor. In this approach, development of a target organ is genetically disabled in a host embryo, and injected donor cells (often from a different species) are coaxed into generating the target organ by the surrounding host cells. Although this interspecies developmental niche is likely more natural than an in vitro model, the in vivo approach to organogenesis comes with its own challenges.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Suchy, Fabian Patrik |
|---|---|
| Degree supervisor | Nakauchi, Hiromitsu, 1952- |
| Thesis advisor | Nakauchi, Hiromitsu, 1952- |
| Thesis advisor | Red-Horse, Kristy |
| Thesis advisor | Sebastiano, Vittorio |
| Degree committee member | Red-Horse, Kristy |
| Degree committee member | Sebastiano, Vittorio |
| Associated with | Stanford University, Department of Stem Cell Biology and Regenerative Medicine |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Fabian P. Suchy. |
|---|---|
| Note | Submitted to the Department of Stem Cell Biology and Regenerative Medicine. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/kh071xt8799 |
Access conditions
- Copyright
- © 2021 by Fabian Patrik Suchy
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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