What do reactive astrocytes do?
Abstract/Contents
- Abstract
- Astrocytes are essential homeostatic regulators of the central nervous system (CNS) environment, maintaining extracellular ion concentrations, shuttling food and waste between neurons and the blood, and recycling neurotransmitters from the synaptic cleft. Astrocytes also respond to disease and injury by undergoing a set of morphological and functional changes collectively called astroglio- sis, but the mechanisms that underlie these changes and their consequence in vivo are poorly under- stood. In this thesis, I investigate the form of reactive astrogliosis that occurs in neuroinflammatory contexts. I review technical challenges in studying reactive glia, characterize reactive astrocytes that form in neuroinflammatory contexts, investigate the impact of neuroinflammatory astrocytes in mouse models of neurodegenerative disease, and outline one mechanism by which astrocytes are toxic to other cells.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Guttenplan, Kevin Alexander |
|---|---|
| Degree supervisor | Gitler, Aaron D |
| Thesis advisor | Gitler, Aaron D |
| Thesis advisor | Li, Lingyin |
| Thesis advisor | Reimer, Richard J |
| Thesis advisor | Zuchero, J |
| Degree committee member | Li, Lingyin |
| Degree committee member | Reimer, Richard J |
| Degree committee member | Zuchero, J |
| Associated with | Stanford University, Neurosciences Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Kevin Alexander Townsend Guttenplan. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/kg207vd1634 |
Access conditions
- Copyright
- © 2021 by Kevin Alexander Guttenplan
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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