Regulation of beta-catenin degradation by the adenomatous polyposis coli protein
Abstract/Contents
- Abstract
- The Wnt/Beta-catenin pathway controls the differentiation and growth of tissues by regulating the stability of the transcription factor Beta-catenin. In the absence of a Wnt growth factor, Beta-catenin is destroyed in a multiprotein complex that contains the protein adenomatous polyposis coli (APC). Over two-thirds of colorectal cancers bear mutations in APC, which leads to inappropriate stabilization of Beta-catenin. Despite its importance, the precise role of APC in Beta-catenin destruction has not been defined. Here I present studies showing the identification of cyclin-dependent kinases as critical for APC's interactions with the Beta-catenin destruction complex. Phosphorylated APC binds directly to the ubiquitin E3 ligase Beta-TrCP and facilitates ubiquitination of Beta-catenin, which is required for its destruction. These findings establish a new link between the cell division cycle and the Wnt growth factor pathway.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Johnston, Darius Michael |
|---|---|
| Degree supervisor | Weis, William I |
| Thesis advisor | Weis, William I |
| Thesis advisor | Ferrell, James Ellsworth |
| Thesis advisor | Jackson, Peter K. (Peter Kent) |
| Thesis advisor | Kopito, Ron Rieger |
| Degree committee member | Ferrell, James Ellsworth |
| Degree committee member | Jackson, Peter K. (Peter Kent) |
| Degree committee member | Kopito, Ron Rieger |
| Associated with | Stanford University, Department of Molecular and Cellular Physiology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Darius Michael Johnston. |
|---|---|
| Note | Submitted to the Department of Molecular and Cellular Physiology. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/kf529pq6215 |
Access conditions
- Copyright
- © 2022 by Darius Michael Johnston
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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