Mapping the therapeutic checkpoints of the STING pathway
Abstract/Contents
- Abstract
- The cGAMP-STING pathway is crucial for the activation of the innate immune system against cancer. This thesis contributes to understanding the regulation of cGAMP in two ways. First, existing tools to quantify cGAMP fall short of scientific needs, particularly in terms of accessibility and throughput. The development of cGAMP-Luc, a high-throughput, sensitive and precise enzymatic assay for the quantitation of cGAMP in complex biological samples bridges this gap. cGAMP-Luc enables the characterization of transporters of cGAMP as well as novel inhibitors of cGAMP hydrolases. Second, the hydrolases of cGAMP are important targets for inhibition in the treatment of cancer. Through studies of ENPP1-/- mice, this thesis explores the existence of cGAMP hydrolases and their physiological relevance in cancer.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Mardjuki, Rachel Elicia |
|---|---|
| Degree supervisor | Li, Lingyin |
| Thesis advisor | Li, Lingyin |
| Thesis advisor | Dassama, Laura |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Degree committee member | Dassama, Laura |
| Degree committee member | Khosla, Chaitan, 1964- |
| Associated with | Stanford University, School of Humanities and Sciences |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Rachel Mardjuki. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/kc070nx0984 |
Access conditions
- Copyright
- © 2023 by Rachel Elicia Mardjuki
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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