New materials for biomedical imaging in the second near-infrared window
Abstract/Contents
- Abstract
- Traditional medical fluorescence imaging uses wavelengths spanning the visible (400-700 nm) and infrared (700-900 nm) regions of the electromagnetic spectrum. These wavelengths display poor optical penetration depths as well as high levels of photon scattering and background autofluorescence. As a result, traditional medical fluorescence imaging cannot effectively resolve features below the surface of the skin (~0.4 mm penetration depths). We have demonstrated that fluorescence imaging past 1000 nm in an optical window termed the second near-infrared window (NIR-II; 1000-1700 nm) reduces the adverse interactions between light and tissue described above, leading to 5-fold higher tumor-to-background ratios with 10-fold deeper tissue penetration depths. Fluorescence imaging in the second near-infrared widow (NIR-II; 1000-1700 nm) is a powerful technique that gives doctors and researchers a view into the human body or turbid biological tissues. However, the development of this imaging modality relies on new materials with advanced optical properties. This work aims to develop highly purified single-walled carbon nanotubes (SWCNTs) of a single diameter with unique optical signatures that lower requisite doses for NIR-II tumor detection and treatment. Although SWCNTs provide a promising approach for future clinical applications, the development of organic NIR-II dyes similar in structure and pharmacokinetics to FDA-approved medical fluorophores is a faster route to the clinic. This work additionally presents the first NIR-II organic dyes with high levels of excretion as well as a high quantum yield.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Antaris, Alexander |
|---|---|
| Associated with | Stanford University, Department of Materials Science and Engineering. |
| Primary advisor | Dai, Hongjie, 1966- |
| Primary advisor | Heilshorn, Sarah |
| Thesis advisor | Dai, Hongjie, 1966- |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Cheng, Zhen, 1973- |
| Advisor | Cheng, Zhen, 1973- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Alexander Antaris. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Alexander Lee Antaris
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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