Polymer-nanoparticle hydrogels : from fundamentals to biomedical applications
Abstract/Contents
- Abstract
- Physically crosslinked hydrogels are an appealing class of materials for biomedical applications including drug delivery, 3D bioprinting, and cell therapies due to their unique mechanical properties, such as injectability. This thesis examines Polymer-Nanoparticle (PNP) hydrogels as one class of these materials that have been found to be effective in biomedical studies requiring minimally invasive injections. We elucidate criteria for the formation of robust PNP hydrogels and highlight key mechanical properties needed for applications. We demonstrate that chemical modifications of the outer corona of the nanoparticles lead to great changes in mechanical properties including extreme extensibility. Using this understanding of hydrogel mechanical properties, we also optimize these materials for the delivery of therapeutic cells for regenerative medicine and immunotherapy applications. We demonstrate the advantages of using PNP hydrogels over liquid saline injections, such as minimizing cell membrane damage during injection and increasing cell retention at the injection site. Leveraging these capabilities, finally we describe the development of PNP hydrogels for the treatment of solid tumors in in vivo cancer models through the improved co-delivery of CAR-T cells and stimulatory cytokines. Overall, this thesis demonstrates that carefully designed dynamic biomaterials enable unique opportunities in biomedicine.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Grosskopf, Abigail Kate |
|---|---|
| Degree supervisor | Appel, Eric (Eric Andrew) |
| Degree supervisor | Fuller, Gerald G |
| Thesis advisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Fuller, Gerald G |
| Thesis advisor | Heilshorn, Sarah |
| Degree committee member | Heilshorn, Sarah |
| Associated with | Stanford University, Department of Chemical Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Abigail Kate Grosskopf. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/jw730pp4750 |
Access conditions
- Copyright
- © 2022 by Abigail Kate Grosskopf
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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