The impact of environmental exposures on the human and mouse gut microbiome
Abstract/Contents
- Abstract
- Advances in sequencing technologies have enabled unprecedented opportunities to characterize the effects of the microbiome on host physiology and the development of disease. Understanding the factors that influence microbiome colonization and stability and that shape immune responses is critical to harness the microbiome as a therapeutic target. In this dissertation, I explore microbiome associations with aberrant immunological conditions. I present my research in human and mouse models characterizing the impact of microbiome altering exposures during critical immune development windows. Chapter 2 describes the first interventional study to assess the impact of common household antimicrobials on the developing gut microbiome during the first year of life. Chapter 3 evaluates the efficacy of prebiotics to enrich for microbes that produce immunomodulatory compounds to offset life-threatening gut inflammatory responses. Chapter 4 describes leveraging the known microbiome differences in mouse models to mine for putative protective species in colonic inflammation. Chapter 5 addresses the application of novel sequencing technologies to overcome the current limitations of measuring the gut microbiome. Overall these chapters provide a better understanding of measuring host-microbial interactions in the context of immune regulation.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Ribado, Jessica |
|---|---|
| Degree supervisor | Bhatt, Ami (Ami Siddharth) |
| Degree supervisor | Pritchard, Jonathan D |
| Thesis advisor | Bhatt, Ami (Ami Siddharth) |
| Thesis advisor | Pritchard, Jonathan D |
| Thesis advisor | Montgomery, Stephen, 1979- |
| Thesis advisor | Negrin, Robert S |
| Degree committee member | Montgomery, Stephen, 1979- |
| Degree committee member | Negrin, Robert S |
| Associated with | Stanford University, Department of Genetics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Jessica Ribado. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Jessica Ribado
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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