Mano a mono : monocytes across disease and vaccination
Abstract/Contents
- Abstract
- The innate immune system is the first line of defense against pathogens. Known best for its quick but short-lived effects, the role of the innate immune cells in chronic disease and vaccination has remained relatively unexplored. This thesis first describes the powerful prognostic use of monocytes, a component of the innate immune system, to better stratify patients with idiopathic pulmonary fibrosis for organ transplant. Next, we demonstrate the long-term response of monocytes in vaccines adjuvanted with 3M-052, a novel innate-immune specific adjuvant. Finally, we show that monocytes are critical responders to the Pfizer-BioNTech COVID mRNA vaccine in the largest single-cell study of an mRNA vaccine to date.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Scott, Madeleine |
|---|---|
| Degree supervisor | Davis, Mark M |
| Degree supervisor | Khatri, Purvesh |
| Thesis advisor | Davis, Mark M |
| Thesis advisor | Khatri, Purvesh |
| Thesis advisor | Pulendran, B. (Bali) |
| Thesis advisor | Utz, PJ |
| Degree committee member | Pulendran, B. (Bali) |
| Degree committee member | Utz, PJ |
| Associated with | Stanford University, Biophysics Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Madeleine KD Scott. |
|---|---|
| Note | Submitted to the Biophysics Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/jq832bk1090 |
Access conditions
- Copyright
- © 2021 by Madeleine Scott
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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