The allostery of transglutaminase 2 and its role in coeliac disease
Abstract/Contents
- Abstract
- Coeliac disease (CeD) is an inflammatory autoimmune disease triggered by the ingestion of gluten that classically presents with abdominal pain, malabsorption, and diarrhea. Virtually all coeliac patients carry human leukocyte antigen (HLA) DQ2 or DQ8 alleles; gluten peptides bind to HLA-DQ2 or HLA-DQ8, and in coeliac patients, this event results in a T-cell response. Gluten peptides contain many glutamine residues which are deamidated in the small intestine by the ubiquitous protein transglutaminase 2 (TG2), and while native gluten peptides are antigenic to coeliac patients, deamidated gluten peptides are considerably more antigenic. However, TG2 is normally inactive in this environment. Being an abundant protein, TG2 possesses an intricate set of allosteric regulatory mechanisms that governs its activity in its many environments. Careful study of TG2 allosteric regulation is integral for a more complete understanding of CeD pathogenesis, and can thus inform the development of more effective therapies or a cure. Additionally, CeD serves as a model autoimmune disease for our study of other autoimmune diseases, as its disease state can be induced with the introduction of an exogenous protein.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Melkonian, Arek Viken |
|---|---|
| Degree supervisor | Khosla, Chaitan, 1964- |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Thesis advisor | Frank, C. W |
| Thesis advisor | Kim, Peter, 1958- |
| Thesis advisor | Porteus, Matthew H |
| Degree committee member | Frank, C. W |
| Degree committee member | Kim, Peter, 1958- |
| Degree committee member | Porteus, Matthew H |
| Associated with | Stanford University, Department of Chemical Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Arek Viken Melkonian. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/jf578zx5215 |
Access conditions
- Copyright
- © 2021 by Arek Viken Melkonian
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