Quantitative measures of gait and reaching in toddlers born preterm with very-low birth-weight
- This dissertation aims to quantitatively analyze functional lower- and upper-extremity movement in toddlers born preterm with very-low birth-weight (VLBW). Children born preterm with VLBW have increased risk of motor impairment, and early identification of impairment guides treatment to improve long-term function. Temporal-spatial parameters were quantified and analyzed in the context of neurodevelopment for two functional tasks: gait and reaching. 81 VLBW (≤1500 g) preterm (≤32 weeks) and 43 typically-developing (TD) toddlers successfully completed motor assessments at 18-22 months of age, adjusted for prematurity. Neurodevelopment of VLBW preterm participants was assessed with Bayley Scales of Infant Development-3rd Edition (BSID-III) motor composite, gross motor, and fine motor scores. Differences in temporal-spatial gait were found between lower-scoring preterm toddlers and TD toddlers, and BSID-III motor scores correlated with gait in preterm children. These differences were quantified in the Toddle Temporal-spatial Deviation Index (Toddle TDI), an index quantifying toddler gait deviation from typical. The Toddle TDI demonstrated sensitivity and specificity to gross motor function, and has potential as an easily-administered, revealing clinical and research gait metric. A new method for measuring temporal-spatial reach parameters with inertial sensors showed good agreement with the current gold standard of 3D marker-based motion capture. Using this method, preterm toddlers demonstrated substantial differences in temporal-spatial reach compared to TD toddlers, and evidence indicated several reach parameters were revealing of function and may be useful as a clinical assessment.
|Type of resource
|electronic; electronic resource; remote
|1 online resource.
|Stanford University, Department of Bioengineering.
|Gold, Garry E
|Gold, Garry E
|Statement of responsibility
|Submitted to the Department of Bioengineering.
|Thesis (Ph.D.)--Stanford University, 2016.
- © 2016 by Katelyn Christine Cahill-Rowley
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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