A GATA transcription factor, egl-27, delays aging by promoting stress resistance in C. elegans
Abstract/Contents
- Abstract
- Stress is a fundamental aspect of aging as accumulated damage from a lifetime of stress can limit lifespan, and protective responses to stress can extend lifespan. In this study, we identify a conserved C. elegans GATA transcription factor, egl-27, that is involved in several stress responses and aging. We found that overexpression of egl-27 extends the lifespan of wild-type animals. Furthermore, egl-27 is required for the pro-longevity effects from impaired insulin/IGF-1 like signaling (IIS), as reduced egl-27 activity fully suppresses the longevity of worms that are mutant for the IIS receptor, daf-2. egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. Consistent with its role in IIS signaling, we found that egl-27 is involved in stress response pathways. egl-27 expression is induced in the presence of multiple stresses, its targets are significantly enriched for many types of stress genes, and altering levels of egl-27 itself affects survival to heat and oxidative stress. Finally, we found that egl-27 expression increases between young and old animals, suggesting that increased levels of egl-27 in aged animals may act to promote stress resistance. These results identify egl-27 as a novel factor that links stress and aging pathways.
Description
Type of resource | text |
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Form | electronic; electronic resource; remote |
Extent | 1 online resource. |
Publication date | 2012 |
Issuance | monographic |
Language | English |
Creators/Contributors
Associated with | Xu, Xiao | |
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Associated with | Stanford University, Program in Cancer Biology. | |
Primary advisor | Kim, Stuart | |
Thesis advisor | Kim, Stuart | |
Thesis advisor | Brunet, Anne, 1972- | |
Thesis advisor | Chua, Katrin Faye | |
Thesis advisor | Snyder, Michael, Ph. D | |
Advisor | Brunet, Anne, 1972- | |
Advisor | Chua, Katrin Faye | |
Advisor | Snyder, Michael, Ph. D |
Subjects
Genre | Theses |
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Bibliographic information
Statement of responsibility | Xiao Xu. |
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Note | Submitted to the Program in Cancer Biology. |
Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Xiao Xu
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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