Chemical approaches to the study of N-glycanase 1 : understanding NGLY1 deficiency and implications in cancer therapy
Abstract/Contents
- Abstract
- N-Glycanase 1 (NGLY1) is the human cytosolic protein N-glycosidase. The relationship between NGLY1 and the transcription factor Nrf1 is examined, particularly observing cellular response to proteasomal stress in healthy, NGLY1 deficient, and cancer model systems using genetic and chemical tools. Additionally, the role of NGLY1 in innate immunological signaling and other stress-response pathways that are regulated by the ERAD pathway is explored. Finally, the further development of the Quadricyclane (QC) ligation, a bioorthogonal reaction between QC and nickel bis(dithiolene) is described.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Tomlin, Frederick M |
|---|---|
| Degree supervisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Kool, Eric T |
| Thesis advisor | Waymouth, Robert M |
| Degree committee member | Kool, Eric T |
| Degree committee member | Waymouth, Robert M |
| Associated with | Stanford University, Department of Chemistry. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Frederick M. Tomlin. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Frederick Michael Tomlin
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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