Design and development of a 1mm resolution clinical positron emission tomography (PET) system
Abstract/Contents
- Abstract
- Positron Emission Tomography (PET) is an in-vivo medical imaging modality that extracts information about molecular processes associated with disease. A PET system produces an image of radiopharmaceuticals that have preferentially accumulated in certain cells of tissues in the body, such as cancerous lesions. Clinical PET systems have about 5-10mm spatial resolution, and thus have difficulty resolving very small lesions. So, improving the resolution of PET is an active area of research. This thesis describes the design of a 1mm resolution PET system for breast cancer imaging and the strategies used to overcome the challenges of developing such a high resolution PET system. The detectors in this PET system consist of lutetium yttrium oxyorthosilicate (LYSO) scintillation crystal arrays coupled to position-sensitive avalanche photodiodes (PSAPDs). There will be over 2000 Dual-LYSO-PSAPD detector modules in the final system, each requiring a bias voltage of 1750 Volts. A programmable high voltage distribution method allows the bias voltage to be optimized for each detector module. Multiplexing of detector signals reduced the number of interconnects by 40% and front-end electronic channels by 33%. Charge division and charge sharing signal conditioning compensate for the mismatch between the detector signal and the front-end electronics input dynamic range, as well as for parasitic capacitance introduced by interconnect. A model of the detectors and electronics was created to help understand the system and to assist in the system design process. Two cartridges of the system, consisting of 256 Dual-LYSO-PSAPD detectors, were constructed and characterized. The system energy resolution was 11% FWHM (full-width-at-half-maximum) and the measured spatial resolution was less than 1mm. The system was able to produce reconstructed images of a phantom with 1.2mm rods filled with a solution of the positron emitter Fluorine-18.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lau, Frances Wing Yee |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering. |
| Primary advisor | Levin, Craig |
| Thesis advisor | Levin, Craig |
| Thesis advisor | Horowitz, Mark (Mark Alan) |
| Thesis advisor | Wooley, Bruce A, 1943- |
| Advisor | Horowitz, Mark (Mark Alan) |
| Advisor | Wooley, Bruce A, 1943- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Frances Wing Yee Lau. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Frances Wing Yee Lau
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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