Unlocking synthetic biomaterials : manufacture of structural biogenic materials via 3D-printed arrays of bioengineered cells
Abstract/Contents
- Abstract
- Many complex, biologically-derived materials have extremely useful properties (think wood or silk), but suf- fer from production, manufacturing, and processing limitations. Cells naturally specialize in making complex biomaterials on a micro scale. This work explores a technology concept combining this ability with the re- cently emergent fields of synthetic biology and additive manufacturing in which the end product is a nonliving biomaterial with human-designed shape, structure and composition. A 3D printer capable of printing living cells with near single-cell resolution is used to create 3D-structured arrays of cells bioengineered to secrete different materials. The cells produce the materials in rates and quantities determined by human-controlled stimuli. A proof of concept is described consisting of a two-material array of non-structural proteins. Each step in the end-to-end demonstration has been proven to reach the minimum level of critical functionality. Adding a vast new set of biomaterials, both natural and newly designed, to the traditional metal, plastic and ceramic material toolkit has applications limited by our future imagination; this work is an important first step on that path.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Gentry, Diana Marron |
|---|---|
| Associated with | Stanford University, Department of Mechanical Engineering. |
| Primary advisor | Kenny, Thomas William |
| Primary advisor | Rothschild, Lynn J |
| Thesis advisor | Kenny, Thomas William |
| Thesis advisor | Rothschild, Lynn J |
| Thesis advisor | Sheppard, S. (Sheri) |
| Advisor | Sheppard, S. (Sheri) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Diana Marron Gentry. |
|---|---|
| Note | Submitted to the Department of Mechanical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Diana Marron Gentry
- License
- This work is licensed under a Creative Commons Attribution Non Commercial Share Alike 3.0 Unported license (CC BY-NC-SA).
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