Regulation & control of multicell behavior : interactive swarm control, collective migration, and synthetic aggregation
Abstract/Contents
- Abstract
- This thesis covers three separate projects investigating the mechanisms and applications of multicellular systems. The first project is a pioneering study in the application of swarms of the protist Euglena gracilis in developing interactive and educational biotechnology. I demonstrate we can control the taxis of these single-celled phototactic organisms with directional light stimuli. Furthermore, I discuss the utility of this phenomena in STEM education through the LudusScope - a do-it-yourself (DIY) platform that includes lessons in electronics, fabrication, programming and biology. I also report on the feedback from both students and teachers about the applicability of the platform in education. The second project discusses the role of the Epithelial Cell-Adhesion Molecule (EpCAM) on migration of multicelluar sheets of epithelial cells. I describe the phenotypic change in sheet migration due to over and under-expression of EpCAM, and report on several protein-protein interactions that are responsible for mediating this change in phenotype. In the last project I discuss the application of synthetic cell-cell adhesion proteins on pattern formation in multi-cell swarms of Escherichia coli. I describe the types of patterns formed by different kinds of cell adhesions, as well as the dynamics of this phenomena. Finally I discuss theoretical models of the phenomena explored through numerical simulations.
Description
| Alternative title | Regulation and control of multicell behavior |
|---|---|
| Type of resource | text |
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Kim, Jung J |
|---|---|
| Degree supervisor | Riedel-Kruse, Hans |
| Thesis advisor | Riedel-Kruse, Hans |
| Thesis advisor | Levenston, Marc Elliot |
| Thesis advisor | Wang, Bo, (Researcher in bioengineering) |
| Degree committee member | Levenston, Marc Elliot |
| Degree committee member | Wang, Bo, (Researcher in bioengineering) |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Jung (Honesty) Kim. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Jung J Kim
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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