Data supporting the publication entitled Reproducibility of Cerebrovascular Reactivity Measurements: A Systematic Review of Neuroimaging Techniques
- Cerebrovascular reactivity (CVR), the capacity of the brain to increase cerebral blood flow (CBF) to meet changes in physiological demand, is an important biomarker to evaluate brain health. Typically, this brain “stress test” is performed by using a medical imaging modality to measure the CBF change between two states: at baseline and after vasodilation. However, since there are many imaging modalities and many ways to augment CBF, a wide range of CVR values have been reported. An understanding of CVR reproducibility is critical to determine the most reliable methods to measure CVR as a clinical biomarker. This review focuses on CVR reproducibility studies using neuroimaging techniques in 32 articles comprising 427 total subjects. The literature search was performed in PubMed, Embase, and Scopus. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We identified 5 factors of the experimental subjects (such as sex, blood characteristics, and smoking) and 9 factors of the measuring technique (such as the imaging modality, the type of the vasodilator, and the quantification method) that have strong effects on CVR reproducibility. Based on this review, we recommend several best practices to improve the reproducibility of CVR quantification in neuroimaging studies.
|Type of resource
|[ca. November 15, 2021]
|November 22, 2021; December 5, 2022
|September 28, 2022
|Research team head
|Systematic reviews (Medical research)
|Brain stress test
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY).
- Preferred citation
- Zhao, M. (2021). Data supporting the publication entitled Reproducibility of Cerebrovascular Reactivity Measurements: A Systematic Review of Neuroimaging Techniques. Stanford Digital Repository. Available at https://purl.stanford.edu/hd852bg4538
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