Dissecting the functions of cadherins in cell-cell adhesion and tissue maintenance
Abstract/Contents
- Abstract
- During normal development, tissue regeneration and cancer, epithelia undergo dramatic morphogenetic processes, ranging from cohesive sheet migration, cell position changes within cohesive tissues, to individual cell migration after dissociation from tissues. Such cell movements require coordination between cell migration and intercellular adhesion to maintaining tissue integrity. In epithelial cells, cell-cell adhesion complexes comprised of cadherins are crucial for these processes. I have investigated the unique roles of different cadherins in assembling adhesion complexes and coordinating migration. I show that cadherins are crucial for directing cellular migration, which is key for processes such as wound healing. The effect on cellular motility depends on the type of cadherin and the corresponding cell-cell complex involved. I show that the two types of desmosomal cadherins, which make up the desmosome, have distinct properties. Thus modulation of desmosomal cadherin interactions during development and cancer may provide a range of adhesive strengths that contributes to the regulation of morphogenetic cell movements.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lowndes, Molly Pleasants |
|---|---|
| Associated with | Stanford University, Cancer Biology Program. |
| Primary advisor | Nelson, W. J. (W. James) |
| Thesis advisor | Nelson, W. J. (W. James) |
| Thesis advisor | Attardi, Laura |
| Thesis advisor | Lipsick, Joseph Steven, 1955- |
| Thesis advisor | Weis, William I |
| Advisor | Attardi, Laura |
| Advisor | Lipsick, Joseph Steven, 1955- |
| Advisor | Weis, William I |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Molly Pleasants Lowndes. |
|---|---|
| Note | Submitted to the Program in Cancer Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Molly Pleasants Lowndes
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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