Elucidating the role of Axin in beta-catenin destruction and stabilization
Abstract/Contents
- Abstract
- Wnts are a family of secreted ligands that regulate embryonic development and stem cell renewal. One way they do so is by increasing cellular concentrations of the transcriptional coactivator beta-catenin by blocking its degradation. As the key scaffold of the beta-catenin destruction complex, Axin promotes beta-catenin degradation. However, it is also essential for the recruitment of the destruction complex to the Wnt-bound receptors to halt beta-catenin destruction in response to a Wnt signal. While most of the essential proteins and many of the key events in Wnt/beta-catenin signal transduction are known, the precise mechanistic logic of both how the beta-catenin destruction completely efficiently destroys beta-catenin in the absence of Wnt and how Wnt binding to its receptors halts this destruction remains unclear. To probe the function of Axin in the Wnt ON and OFF states, structural, biochemical, and enzymatic analyses of the interactions among Axin, GSK-3, beta-catenin, and Dishevelled were carried out. These results inform our understanding of this fundamental signaling pathway
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Enos, Michael David |
|---|---|
| Degree supervisor | Weis, William I |
| Thesis advisor | Weis, William I |
| Thesis advisor | Ferrell, James Ellsworth |
| Thesis advisor | Nusse, Roel, 1950- |
| Degree committee member | Ferrell, James Ellsworth |
| Degree committee member | Nusse, Roel, 1950- |
| Associated with | Stanford University, Department of Structural Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Michael David Enos |
|---|---|
| Note | Submitted to the Department of Structural Biology |
| Thesis | Thesis Ph.D. Stanford University 2021 |
| Location | https://purl.stanford.edu/gy493zf6621 |
Access conditions
- Copyright
- © 2021 by Michael David Enos
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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