Regulatory and cellular dynamics in cancer
Abstract/Contents
- Abstract
- Improving and maintaining durable clinical responses to cancer therapies requires a detailed understanding of regulatory dynamics that underlie altered gene expression in cancer cells and as well as the cellular dynamics of cancer and immune cells during cancer progression and in response to therapy. Towards this goal, my dissertation research focuses on the following areas: First, I describe the development of a computational and experimental method to enable high-throughput, low-cost analysis of chromatin accessibility. Second, I characterize the immune cell response to immune checkpoint blockade and find that the clonal T cell response to PD-1 blockade consists of novel clonotypes that had not previously been observed in the same tumor, a process we term clonal replacement. Third, I identify Polycomb-associated DNA loops in stem cells that span tens to hundreds of megabases and enable long-range spreading of the repressive histone modification H3K27me3. Finally, I show that extrachromosomal DNA clusters in the nucleus of interphase cells to promote intermolecular enhancer-promoter interactions and high levels of oncogene expression.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Yost, Kathryn Elizabeth |
|---|---|
| Degree supervisor | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Thesis advisor | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Thesis advisor | Curtis, Christina |
| Thesis advisor | Greenleaf, William James |
| Thesis advisor | Khavari, Paul A |
| Degree committee member | Curtis, Christina |
| Degree committee member | Greenleaf, William James |
| Degree committee member | Khavari, Paul A |
| Associated with | Stanford University, Cancer Biology Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Kathryn Yost. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/gy194ky2113 |
Access conditions
- Copyright
- © 2021 by Kathryn Elizabeth Yost
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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