Advances towards the development of an artificial pancreas
Abstract/Contents
- Abstract
- Type 1 diabetes is characterized by autoimmune islet beta cell destruction and insulin deficiency. Islet transplantation is a heavily targeted therapy for type 1 diabetes, as it would provide a continually replenishing source of insulin. However, current therapy requires lifelong immunosuppression. Cell encapsulation would overcome the need for immunosuppression but introduces new challenges to providing insulin release on a physiologically relevant timescale. Here, I present a novel approach for electronically actuated insulin release from encapsulated islets and beta cells, via applied pressure. I demonstrate the efficacy of this release approach for insulin bolus delivery and improved glycemic control. I also discuss the development of a line of genetically engineered beta cells to release various "peptides-of-interest" targeted for a multi-hormonal artificial pancreas. Finally, I introduce the design and characterization of a miniaturized wireless potentiostat for sensing of salivary glucose and lactate. Detection of salivary lactate could provide insight into exercise intensity and improve glycemic control for an artificial pancreas. Together, these developments overcome key limitations of current artificial pancreas designs.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Thomson, Ella Ainsley |
|---|---|
| Degree supervisor | Poon, Ada Shuk Yan |
| Thesis advisor | Poon, Ada Shuk Yan |
| Thesis advisor | Annes, Justin |
| Thesis advisor | Pauly, John (John M.) |
| Degree committee member | Annes, Justin |
| Degree committee member | Pauly, John (John M.) |
| Associated with | Stanford University, Department of Electrical Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Ella Thomson. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/gv752jp4153 |
Access conditions
- Copyright
- © 2022 by Ella Ainsley Thomson
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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