Mechanical regulation of tight junction organization and function in epithelial cells
Abstract/Contents
- Abstract
- Cell-cell junctions play a critical role in development and maintaining tissue homeostasis in adult tissues. Cell junctions establish and maintain adhesion, form barriers within cellular membranes and between cells, and are known to regulate many cellular processes. The tight junction is the most apical junction in epithelial cells and is responsible for establishing polarity, forming a barrier for both the diffusion of proteins and paracellular permeability, and regulating cell proliferation. For my thesis work I have dedicated my research to investigating the effect of acute external mechanical forces on the structure and function of tight junctions to regulate paracellular permeability. The organization of tight junction strands, which is a network of tight junction polymers that encircle the entire cell, is one structure that is known to provide insights on barrier function. Additionally, I have investigated the molecular organization of the tight junction, which contains several scaffold proteins, which may bind and regulate to signaling proteins in addition to linking tight junctions to the actin cytoskeleton. Tight junctions are dynamic and respond to mechanical forces through various regulating the composition of proteins at junctions.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Chavez, Natalie |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Nelson, William |
| Thesis advisor | Nelson, William |
| Thesis advisor | Kopito, Ron Rieger |
| Thesis advisor | O'Brien, Lucy |
| Thesis advisor | Weis, William I |
| Advisor | Kopito, Ron Rieger |
| Advisor | O'Brien, Lucy |
| Advisor | Weis, William I |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Natalie Chavez. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Natalie Chavez
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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