Host metabolism controls malaria outcome
Abstract/Contents
- Abstract
- Malaria, caused by infection with members of the genus Plasmodium, causes the death of over 400,000 people, mostly children under age 5, every year. With the increasing prevalence of resistance to antimalarial drugs, new therapies that treat malaria are desperately needed. In order to survive infection, an infected organism must both restrict pathogen load and limit tissue damage. Recent studies have shown that an organism's ability to control tissue damage requires adaptation to the metabolic needs of infection. While the ways that hosts restrict pathogen load during malaria are relatively well-studied, the causes of tissue damage during infection are less clear. This work examines how metabolism affects tissue damage and malaria outcome. Chapter 1 of this dissertation discusses the types and causes of tissue damage during malaria. Chapter 2 uses a multi-omic approach to describe host metabolism, as well as immune responses and pathology, during a mouse model of malaria. As a proof of principle, I demonstrate the importance of a metabolite signaling pathway in limiting tissue damage. In Chapter 3, I describe the interaction between metabolism, fever, and infection outcome and detail ongoing work to develop mouse models that will allow experimental dissection of fever during malaria. Lastly, Chapter 4 reflects on current malaria therapeutics and discusses objectives for the next generation of drugs. Taken together, the work described here highlights the importance of metabolic adaptation to malaria in limiting tissue damage and advocates for development of models and experimental approaches that elucidate the causes of tissue damage during infection.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Lissner, Michelle Marie |
|---|---|
| Degree supervisor | Schneider, David (David Samuel) |
| Thesis advisor | Schneider, David (David Samuel) |
| Thesis advisor | Dodd, Dylan |
| Thesis advisor | Monack, Denise M |
| Thesis advisor | Mudgett, Mary Beth, 1967- |
| Degree committee member | Dodd, Dylan |
| Degree committee member | Monack, Denise M |
| Degree committee member | Mudgett, Mary Beth, 1967- |
| Associated with | Stanford University, Department of Microbiology and Immunology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Michelle Lissner. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Michelle Marie Lissner
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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