A cellular roadmap of ribosome heterogeneity that controls stem cell fate and organismal development
Abstract/Contents
- Abstract
- The regulation of translation is fundamental to the diversification and control of gene expression across cell types and tissues. The processes of stem cell renewal and differentiation have been reported to be particularly sensitive to changes in protein synthesis, suggesting that finely tailored translation is necessary for the proper regulation of gene expression during cell fate specification, but the mechanisms underlying this translational control remain poorly understood. A source for this regulation may be the ribosome itself, which has recently been shown to be heterogeneous in composition within mouse embryonic stem cells, with distinct ribosomal populations specialized for the translation of particular sets of mRNA transcripts. However, as ribosome heterogeneity has previously been measured only within individual cell types, we lack a systematic view of how ribosome composition changes across development and whether particular ribosome compositions have tissue-specific functions. To this end, I present work delineating changes in ribosome composition across cell differentiation and identifying specialized functions for ribosomal components in the translation of core developmental signaling pathways needed for organismal patterning.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Genuth, Naomi Rebecca |
|---|---|
| Degree supervisor | Barna, Maria, (Professor of developmental biology) |
| Thesis advisor | Barna, Maria, (Professor of developmental biology) |
| Thesis advisor | Puglisi, Joseph D |
| Thesis advisor | Red-Horse, Kristy |
| Thesis advisor | Stearns, Tim |
| Degree committee member | Puglisi, Joseph D |
| Degree committee member | Red-Horse, Kristy |
| Degree committee member | Stearns, Tim |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Naomi Rebecca Genuth. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/gr982kc6837 |
Access conditions
- Copyright
- © 2021 by Naomi Rebecca Genuth
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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