Harnessing the tumor microenvironment to enhance ovarian cancer immunotherapy
Abstract/Contents
- Abstract
- The five-year survival rate for ovarian cancer remains low despite improvements in therapy and many patients with advanced disease relapse following treatment. For a small subset of patients that have failed other treatment options, immune checkpoint blockade can provide beneficial responses, yet the majority of patients will experience progressive disease13. The goal of the work presented here is to explore options to target the tumor microenvironment in combination with existing immunotherapies to improve their efficacy. PMN-MDSCs are known to contribute to poor cancer outcomes and resistance to immunotherapy, yet we lack clinical therapies to target them. In the first part of this thesis, we identified the IL-5Rα/IL-33/ST2 signaling axis as a potential method to target PMN-MDSCs. In the second part, we demonstrated that FLASH irradiation can provide a safe and effective means to increase anti-tumor T cell activity in combination with αPD-1 checkpoint blockade. Future translational work in both of these areas will hopefully lead to the development of new treatment paradigms for ovarian cancer.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Eggold, Joshua Thomas |
|---|---|
| Degree supervisor | Rankin, Erinn |
| Thesis advisor | Rankin, Erinn |
| Thesis advisor | Engleman, Edgar G |
| Thesis advisor | Graves, Edward (Edward Elliot), 1974- |
| Thesis advisor | Sunwoo, John B |
| Degree committee member | Engleman, Edgar G |
| Degree committee member | Graves, Edward (Edward Elliot), 1974- |
| Degree committee member | Sunwoo, John B |
| Associated with | Stanford University, Cancer Biology Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Joshua T. Eggold. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/gn292cy0095 |
Access conditions
- Copyright
- © 2021 by Joshua Thomas Eggold
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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