Species-specific characteristics of biological processes in development and aging
Abstract/Contents
- Abstract
- The evolutionary process of speciation divides a population into separate groups, which with time, develop characteristics that differentiate it from each other. Despite this, they contain remnants, whether it be physical characteristics or at the molecular level, which tie them to a common ancestor. These similarities have allowed us to use model organisms to deduce biological phenomena in different species. This is an extremely valuable and important resource, especially for understanding human biology, where the study of certain biological processes, such as early development using human embryos, is ethically prohibited. However, despite the availability of these resources, many of these processes remain understudied. And while species with shorter evolutionary distance often retain more of the same physical features, this does not guarantee that all biological processes function the same. This reminds us to proceed with caution as we make cross-species interpretations. This thesis addresses these issues by interrogating the similarities and differences between species through two different angles. (1) The first is a direct comparison of the same biological process, early pregnancy, in various species. Through this work, we identify and characterize these novel species-specific features. (2) I will also hone in on the biological process of one species to identify how both conserved and species-specific characteristics can change depending on the experimental environment (in vivo and ex vivo) and with aging. To do this, I look at mouse hematopoiesis, blood cell production, identifying these changes throughout the whole organismal life span, starting from development to aging. Both approaches shed a new light on our understanding of what factors underly species specificity and conserved characteristics.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2024; ©2024 |
| Publication date | 2024; 2024 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Igarashi, Kyomi Jane |
|---|---|
| Degree supervisor | Baker, Julie, (Professor of genetics) |
| Degree supervisor | Nakauchi, Hiromitsu, 1952- |
| Thesis advisor | Baker, Julie, (Professor of genetics) |
| Thesis advisor | Nakauchi, Hiromitsu, 1952- |
| Thesis advisor | Bhatt, Ami (Ami Siddharth) |
| Thesis advisor | Villeneuve, Anne, 1959- |
| Degree committee member | Bhatt, Ami (Ami Siddharth) |
| Degree committee member | Villeneuve, Anne, 1959- |
| Associated with | Stanford University, School of Medicine |
| Associated with | Stanford University, Department of Genetics |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Kyomi J. Igarashi. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis Ph.D. Stanford University 2024. |
| Location | https://purl.stanford.edu/gh613pn2486 |
Access conditions
- Copyright
- © 2024 by Kyomi Jane Igarashi
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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