The role of molecular elasticity in biopolymers and protein self-assembly
Abstract/Contents
- Abstract
- Molecular structure of many polymers including biopolymers creates elastic rigidity that impacts polymers behavior. Understanding this impact is critical to address the physics describing variety of single-molecule experiments and biological processes. Utilizing analytical theories and numerical methods, we illustrate the effect of molecular elasticity on the behavior of single molecules employed in single-molecule experiments as well as the morphology of assemblages in protein self-assembly processes. Single-molecule experiments are employed to characterize thermodynamics and kinetics of biomolecules such as DNA and RNA during biomolecular processes. In these experiments, we address the effect of thermal fluctuation, focusing on the equilibrium statistical behavior of specific class of underling single molecules, which act as semiflexible polymers, to gain insight into the physics governing their behavior. To demonstrate the role that molecular elasticity plays in protein self-assembly processes, we focus on clathrin protein, a protein recruited by the cell wall for ingesting food particles during endocytosis. We demonstrate that molecular elasticity and binding affinity have a significant impact on the versatile equilibrium and non-equilibrium assemblages occurred in clathrin protein self-assemby process. These results are essential in guiding experiments utilizing clathrin proteins in biotemplating for self-assembly of nanostructures.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Copyright date | 2012 |
| Publication date | 2011, c2012; 2011 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Mehraeen, Shafigh |
|---|---|
| Associated with | Stanford University, Department of Mechanical Engineering |
| Primary advisor | Spakowitz, Andrew James |
| Thesis advisor | Spakowitz, Andrew James |
| Thesis advisor | Doniach, S |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Shaqfeh, Eric S. G. (Eric Stefan Garrido) |
| Advisor | Doniach, S |
| Advisor | Heilshorn, Sarah |
| Advisor | Shaqfeh, Eric S. G. (Eric Stefan Garrido) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Shafigh Mehraeen. |
|---|---|
| Note | Submitted to the Department of Mechanical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Shafigh Mehraeen
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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