Theoretical and experimental evolution studies of adaptation under diploidy and epistasis
Abstract/Contents
- Abstract
- The dynamics of adaptive evolution is explored in the context of diploidy and epistasis. In the first chapter I model the dynamics of adaptation in the framework of Fisher's geometric model for diploids and find that balancing selection due to heterozygote advantage naturally emerges during adaptation. In the second chapter I explore patterns of divergence and adaptation emerging in a model incorporating functional linkage between genes. Finally, in the third chapter I describe an evolutionary experiment where a populations of a diploid yeast strain adapt to glucose-limited continuous cultures by overdominant mutations, result that supports the predictions of the model from chapter 1.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Sellis, Diamantis |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Petrov, Dmitri Alex, 1969- |
| Thesis advisor | Petrov, Dmitri Alex, 1969- |
| Thesis advisor | Feldman, Marcus W |
| Thesis advisor | Fisher, Daniel |
| Thesis advisor | Fraser, Hunter B |
| Thesis advisor | Sherlock, Gavin |
| Advisor | Feldman, Marcus W |
| Advisor | Fisher, Daniel |
| Advisor | Fraser, Hunter B |
| Advisor | Sherlock, Gavin |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Diamantis Sellis. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Diamantis Sellis
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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