Electronic control of organs : secretory glands and blood vessels
- Electro-neural stimulation can control organ function and help treat disease. Bioelectronic medicine and electrical control of organs are poised to become major new alternatives to traditional pharmacological treatments of disease. This work presents two examples of electronic control of organs: secretion from ocular glands and constriction of blood vessels. Dry eye disease afflicts 100 million people world-wide and originates from a deficiency of tear volume, lipid or protein in the corneal tear film. This work describes the pathways for enhanced secretion of tears by electrical stimulation of the lacrimal gland and sensory nerves, the composition of electrically enhanced tears and the optimal electrical parameters for aqueous secretion. This field has advanced from our basic animal work to clinical trials showing improved symptoms, tear volume, and ocular surface health in dry eye patients. Secondly, we describe electrical vasoconstriction to treat non-compressible hemorrhage—a leading cause of death in military and in civilian trauma. We show that electrical stimulation can reduce the rate of bleeding between 3- and 10-fold through neural and non-neural pathways of vasoconstriction. We designed a prototype of a battery-powered, miniature neurostimulator that could provide hours of vessel control.
|Type of resource
|electronic; electronic resource; remote
|1 online resource.
|Brinton, Mark Richard
|Stanford University, Department of Electrical Engineering.
|Poon, Ada Shuk Yan
|Poon, Ada Shuk Yan
|Statement of responsibility
|Mark Richard Brinton.
|Submitted to the Department of Electrical Engineering.
|Thesis (Ph.D.)--Stanford University, 2017.
- © 2017 by Mark Richard Brinton
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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