Epistasis and evolution
Abstract/Contents
- Abstract
- Most biological traits depend on the interactions among many different genes; these genetic interactions are known as "epistasis." In the first part of this thesis, I examine the evolution of the general pattern of epistasis among deleterious mutations. I find that recombination and population structure create selective pressures favoring different forms of epistasis. In the second part, I consider a particular form of epistasis, known as a "fitness valley, " in which a possible adaptation requires a combination of multiple individually deleterious of neutral mutations to provide a fitness benefit. I find that large populations can rapidly cross shallow fitness valleys, especially if there is a small amount of recombination among the necessary mutations, while they cannot cross deep valleys if recombination is too frequent.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2010 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Weissman, Daniel Benjamin |
|---|---|
| Associated with | Stanford University, Department of Physics |
| Primary advisor | Feldman, Marcus W |
| Primary advisor | Fisher, Daniel S |
| Thesis advisor | Feldman, Marcus W |
| Thesis advisor | Fisher, Daniel S |
| Thesis advisor | Kivelson, Steven |
| Thesis advisor | Petrov, Dmitri Alex, 1969- |
| Thesis advisor | Tuljapurkar, Shripad, 1951- |
| Advisor | Kivelson, Steven |
| Advisor | Petrov, Dmitri Alex, 1969- |
| Advisor | Tuljapurkar, Shripad, 1951- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Daniel B. Weissman. |
|---|---|
| Note | Submitted to the Department of Physics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2010. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2010 by Daniel Benjamin Weissman
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