Regulation of KRAS by SNAREs and noncoding RNAs with therapeutic approaches to treatment
Abstract/Contents
- Abstract
- Human malignancies exact a heavy toll on human life expectancy and productive working years even in developed societies with access to leading medical care. Underlying intractable cancers is an innumerable number of inciting factors, all interconnected into an adaptive entity designed to persist and empowered with the tools that enable life itself. Here, we describe work investigating the mechanistic nuances of how a growth factor signaling cascade is regulated by a series of vesicular transport mechanisms modulated by non-coding RNA. These findings lead us to investigate new therapeutic options to treatment and the development of two in-silico methods to accelerate targeted drug discovery in cancer
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Che, Yonglu |
|---|---|
| Degree supervisor | Khavari, Paul A |
| Thesis advisor | Khavari, Paul A |
| Thesis advisor | Oro, Anthony, 1958- |
| Thesis advisor | Sage, Julien |
| Thesis advisor | Stearns, Tim |
| Degree committee member | Oro, Anthony, 1958- |
| Degree committee member | Sage, Julien |
| Degree committee member | Stearns, Tim |
| Associated with | Stanford University, Cancer Biology Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Yonglu Che |
|---|---|
| Note | Submitted to the Cancer Biology Program |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Yonglu Che
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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