Translational cardiovascular surgical engineering for enhanced biomechanics and device development
- Valvular heart disease is a significant cause of global morbidity and mortality, and most of these diseases are rooted in nuanced biomechanical changes. While surgical intervention has been a mainstay for treatment of many conditions, techniques and devices have been developed primarily based on anatomic principles and guided by appearance and function of the diseased valve, yet new innovations in ex vivo cardiac simulation have enabled the rapid and safe testing of surgical operations and therapies, offering new insights into the nuances of valvular disease and repair. This dissertation contributes to and expands upon the field of study of valvular diseases and surgical treatments and devices as well as modeling modalities and the engineering tools to study these diseases and innovate new solutions for a wide range of diseases including mitral valve prolapse, systolic anterior motion, annular dilation, rheumatic mitral valve, COVID-19, and various aortic pathologies. The following research work has resulted in a significant clinical impact on valvular repair as well as prosthesis and device design, and this work will continue to serve as a foundation for the future expansion of translational cardiovascular surgical engineering, bringing science to art to improve patient care around the world.
|Type of resource
|electronic resource; remote; computer; online resource
|1 online resource.
|Park, Matthew Hee-Joon
|Degree committee member
|Stanford University, School of Engineering
|Stanford University, Department of Mechanical Engineering
|Statement of responsibility
|Matthew Hee-Joon Park.
|Submitted to the Department of Mechanical Engineering.
|Thesis Ph.D. Stanford University 2023.
- © 2023 by Matthew Hee-Joon Park
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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