Understanding Schwann cell mechanisms of myelin debris clearance after peripheral nerve injury
Abstract/Contents
- Abstract
- Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and injured CNS is the pro- and antiregenerative responses of their glial cell populations. Schwann cells undergo a remarkable transformation after PNS injury into a specialized cell type that coordinates and aids peripheral nerve regeneration and repair. The work that follows is based on the hypothesis that by better understanding the Schwann cell response to injury, we might devise novel strategies for overcoming CNS regeneration failure. Specifically, we perform mechanistic studies of a key function of the post-injury Schwann cell, myelin clearance, and provide evidence that Schwann cells clear myelin debris using TAM receptor-mediated phagocytosis as well as autophagy. In collaborative studies, we also examine how the Schwann cell response to injury is altered in the aged PNS, in which regeneration and functional recovery are delayed. We demonstrate that Schwann cell plasticity is decreased in the aged PNS, resulting in delays in Schwann cell repair functions, including myelin clearance. Coupled with recent advances in our understanding of the CNS glial response to injury, these findings provide improved mechanistic insight into why the CNS does not regenerate and how the glial response to CNS insult might be manipulated to better support CNS repair.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2017 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Brosius Lutz, Amanda |
|---|---|
| Associated with | Stanford University, Department of Developmental Biology. |
| Primary advisor | Barres, Ben |
| Thesis advisor | Barres, Ben |
| Thesis advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Thesis advisor | Fuller, Margaret T, 1951- |
| Thesis advisor | Talbot, William |
| Advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Advisor | Fuller, Margaret T, 1951- |
| Advisor | Talbot, William |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Amanda Brosius Lutz. |
|---|---|
| Note | Submitted to the Department of Developmental Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2017. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2017 by Amanda Ramsay Brosius Lutz
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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