Understanding Schwann cell mechanisms of myelin debris clearance after peripheral nerve injury

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Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and injured CNS is the pro- and antiregenerative responses of their glial cell populations. Schwann cells undergo a remarkable transformation after PNS injury into a specialized cell type that coordinates and aids peripheral nerve regeneration and repair. The work that follows is based on the hypothesis that by better understanding the Schwann cell response to injury, we might devise novel strategies for overcoming CNS regeneration failure. Specifically, we perform mechanistic studies of a key function of the post-injury Schwann cell, myelin clearance, and provide evidence that Schwann cells clear myelin debris using TAM receptor-mediated phagocytosis as well as autophagy. In collaborative studies, we also examine how the Schwann cell response to injury is altered in the aged PNS, in which regeneration and functional recovery are delayed. We demonstrate that Schwann cell plasticity is decreased in the aged PNS, resulting in delays in Schwann cell repair functions, including myelin clearance. Coupled with recent advances in our understanding of the CNS glial response to injury, these findings provide improved mechanistic insight into why the CNS does not regenerate and how the glial response to CNS insult might be manipulated to better support CNS repair.


Type of resource text
Form electronic; electronic resource; remote
Extent 1 online resource.
Publication date 2017
Issuance monographic
Language English


Associated with Brosius Lutz, Amanda
Associated with Stanford University, Department of Developmental Biology.
Primary advisor Barres, Ben
Thesis advisor Barres, Ben
Thesis advisor Clandinin, Thomas R. (Thomas Robert), 1970-
Thesis advisor Fuller, Margaret T, 1951-
Thesis advisor Talbot, William
Advisor Clandinin, Thomas R. (Thomas Robert), 1970-
Advisor Fuller, Margaret T, 1951-
Advisor Talbot, William


Genre Theses

Bibliographic information

Statement of responsibility Amanda Brosius Lutz.
Note Submitted to the Department of Developmental Biology.
Thesis Thesis (Ph.D.)--Stanford University, 2017.
Location electronic resource

Access conditions

© 2017 by Amanda Ramsay Brosius Lutz
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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