Empirical assessment of practices and bias across diverse research domains

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Abstract/Contents

Abstract
Research today is expensive, time consuming, and low yield. Much work has been done to describe research practices and quantify biases that may contribute to this. However, new ways of conducting research are constantly being proposed. Potential biases may not be as well characterized for these new fields. I aimed to describe the prevalence of practices and potential for biases in three relatively new and fast-growing fields. Specifically, these included: comparative oncology trials in domestic dogs, E-values for sensitivity analysis in observational studies, and machine learning diagnostic tools. Primary research articles were systematically retrieved from literature databases. Data regarding research methodology, reporting, and study results were extracted. In addition to field-specific findings, conserved trends were observed across multiple fields, including a reluctance to report experimental details, a tendency for facile automation in methods and interpretation, and an opportunity to learn from adjacent fields. The present study identifies pitfalls that threaten the validity, generalizability, and clinical value of these three fields of research and provides recommendations for improvement

Description

Type of resource text
Form electronic resource; remote; computer; online resource
Extent 1 online resource
Place California
Place [Stanford, California]
Publisher [Stanford University]
Copyright date 2020; ©2020
Publication date 2020; 2020
Issuance monographic
Language English

Creators/Contributors

Author Tan, Yuan Jin
Degree supervisor Ioannidis, John
Thesis advisor Ioannidis, John
Thesis advisor Goodman, Steven R
Thesis advisor Grimes, Kevin
Thesis advisor Sainani, Kristin
Degree committee member Goodman, Steven R
Degree committee member Grimes, Kevin
Degree committee member Sainani, Kristin
Associated with Stanford University, Department of Epidemiology and Population Health.

Subjects

Genre Theses
Genre Text

Bibliographic information

Statement of responsibility Yuan Jin Tan
Note Submitted to the Department of Epidemiology and Population Health
Thesis Thesis Ph.D. Stanford University 2020
Location electronic resource

Access conditions

Copyright
© 2020 by Yuan Jin Tan
License
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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