Multi-omic characterization of segmental graft dysfunction in liver transplant patients
Abstract/Contents
- Abstract
- Liver transplantation was pioneered in canine models in the 1950s and extended to humans in the 1960s. Since then, improvements in recipient-donor matching, organ allocation policies, and immunosuppression have made transplantation a viable intervention for patients with end-stage liver disease. Nowadays, the 5-year survival rate is 75%, with the majority of transplant failures occurring within 90 days after surgery. The success of liver transplantation is overshadowed by the significant organ shortage which motivated the inclusion of living donors. Within the first week after receiving a partial liver graft, patients could experience segmental graft dysfunction (SGD), a form of early allograft dysfunction (EAD). Although the majority of patients recover, an SGD diagnosis is still predictive of graft failure. This thesis focuses on determining the molecular signatures underpinning the development of SGD and developing predictive models of graft failure to identify high-risk patients.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Erazo Castillo, Kevin Paul |
|---|---|
| Degree supervisor | Snyder, Michael, Ph. D. |
| Thesis advisor | Snyder, Michael, Ph. D. |
| Thesis advisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Degree committee member | Bertozzi, Carolyn R, 1966- |
| Degree committee member | Khosla, Chaitan, 1964- |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Kevin Paul Erazo Castillo. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/fr977vj0087 |
Access conditions
- Copyright
- © 2022 by Kevin Paul Erazo Castillo
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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