Data for "Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region"

<a href="https://embed.stanford.edu/iframe/?url=https%3A%2F%2Fpurl.stanford.edu%2Ffq418zt1728" class="su-underline">Show Content</a>

Abstract/Contents

Abstract: Background: The Nicoya Peninsula in Costa Rica has one of the highest old age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation has become an increasingly important part of aging research, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a particular social, biological and environmental context. Results: By investigating DNA methylation profiles of Nicoyans and other Costa Ricans, we observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, a suggestive hallmark of younger biological age. Conclusions: In summary, Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.

Type of resource	software, multimedia
Date created	2015 - 2017

Author	McEwan, Lisa M.
Author	Rehkopf, David H.

Subject	School of Medicine
Subject	Department of Medicine
Subject	Division of Primary Care & Population Health
Subject	Population Health Sciences
Subject	Health Research and Policy
Subject	Epidemiology
Subject	DNA methylation
Subject	Costa Rica
Subject	Nicoya
Genre	Dataset

Related Publication	McEwen, LM, Morin, AM, Edgar, RD, MacIsaac, JL, Jones, MJ, Dow, WH, Rosero-Bixby, L, Kobor, MS, Rehkopf, DH. (2017). Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. Epigenetics and Chromatin. 10:21. https://doi.org/10.1186/s13072-017-0128-2
Location	https://purl.stanford.edu/fq418zt1728

Use and reproduction: User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
License: This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).

Preferred Citation: McEwan, Lisa M. and Rehkopf, David H. (2017). Data for "Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region". Stanford Digital Repository. Available at: https://purl.stanford.edu/fq418zt1728

Stanford Research Data

Loading usage metrics...