Nanoengineering and knockoffs for an electronic molecular fingerprinting platform
Abstract/Contents
- Abstract
- To diagnose complex diseases and perform advanced drug screening and chemical monitoring, we need sensors capable of broadband, multi-analyte detection. This is achieved either by multiplexing affinity probes to capture different target analytes, or through mass or vibrational spectroscopy. While affinity-based techniques currently dominate and are capable of high specificity and sensitivity, probe multiplexing can be time consuming, expensive, and difficult to execute reliably outside of a laboratory environment. On the other hand, spectroscopic chemical detection is label- and affinity-free, but often requires costly and bulky instrumentation. In this thesis, we describe an affinity-free sensor for measuring vibrational signatures of analytes in liquid samples, which can be implemented on a scalable and fully-electronic platform. This relies on resonant electrochemical charge transfer at room temperature, which is made possible by nanoscale interface engineering and low-noise potentiostatic feedback. We describe advances in the knowledge and technology required to realize key aspects of this platform, including the nanoscale sensor site, electrochemical measurement system, and signal analysis framework. Together, these pave the way for continued development of a practical electronic platform for molecular fingerprinting platform in complex samples.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Chia, Charmaine Jing Ting |
|---|---|
| Degree supervisor | Howe, Roger Thomas |
| Thesis advisor | Howe, Roger Thomas |
| Thesis advisor | Jeffrey, Stefanie |
| Thesis advisor | Soh, H. Tom |
| Degree committee member | Jeffrey, Stefanie |
| Degree committee member | Soh, H. Tom |
| Associated with | Stanford University, Department of Electrical Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Charmaine Chia. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Charmaine Jing Ting Chia
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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