Urban Risk Factors for Human Rift Valley Fever virus exposure in Kenya
Abstract/Contents
- Abstract
- The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle those risk factors from other livestock rearing activities. Urban areas have an increased demand for animal source foods, different vector distributions, and various arboviruses are understood to establish localized urban transmission cycles. Thus far, RVFV is an unevaluated public health risk in urban areas within endemic regions. We tested participants in our ongoing urban cohort study on dengue (DENV) and chikungunya (CHIKV) virus for RVFV exposure and found 1.6% (57/3,560) of individuals in two urban areas of Kenya had anti-RVFV IgG antibodies. 88% (50/57) of RVFV exposed participants also had co-exposure to DENV, CHIKV, or both. Although livestock ownership was very low in urban study sites, RVFV exposure was significantly associated with seeing goats and poultry around the homestead (p=0.04) and consumption of raw milk (p=0.02) in multivariate modeling. Risk of exposure to RVFV was three times higher (OR=3.3 [95%CI: 0.86-12.5], p=0.07) among those buying unpasteurized milk from milk vendors or directly from dairy owners compared to those that purchased commercialized packets of milk. In addition, lack of piped water and use of small jugs (15-20 liters) for water was associated with a higher risk of RVFV exposure (p=0.002) and may contribute to interepidemic vector-borne maintenance of RVFV. This study provides baseline evidence to guide future studies investigating the urban potential of RVFV and highlights the unexplored role of animal products in continued spread of RVFV.
Description
| Type of resource | Dataset, text |
|---|---|
| Date created | [ca. January 1, 2021 - August 10, 2021] |
| Date modified | December 5, 2022 |
| Publication date | January 20, 2022; January 2022 |
Creators/Contributors
| Author | Gerken, Keli |
|---|---|
| Author | LaBeaud, Desiree |
| Author | Mutuku, Francis |
| Author | Ndenga, Bryson |
| Author | Agola, Gladys |
| Author | Rezende, Izabela |
| Author | Shaita, Karren |
| Author | Fabre, Eduardo |
| Author | Migliore, Eleonora |
Subjects
| Subject | Rift Valley Fever, RVFV, epidemiology, Kenya, urban, zoonotic |
|---|---|
| Genre | Data |
| Genre | Tabular data |
| Genre | Data sets |
| Genre | Dataset |
| Genre | Tables (data) |
Bibliographic information
Access conditions
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- License
- This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY).
Preferred citation
- Preferred citation
- Gerken, K., Mutuku, F., Ndenga, B., Agola, G., Rezende, I., Shaita, K., Fabre, E., Migliore, E., and LaBeaud, D. (2022). Urban Risk Factors for Human Rift Valley Fever virus exposure in Kenya. Stanford Digital Repository. Available at https://purl.stanford.edu/fp177dq8431
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