Recognition of hapten molecules by gamma delta T cells
Abstract/Contents
- Abstract
- The adaptive immune system is composed of [alpha beta] T cells, [gamma delta] T cells, and B cells, all of which express diverse rearranged antigen receptors and have been conserved together through evolution. [gamma delta] T cells make up the minority of circulating T cells and perform many of the same effector functions as [alpha beta] T cells, including cytotoxic functions and the production of cytokines like IL-17, IFN-[gamma], and IL-4. However, the conservation of [gamma delta] T cells suggests that they fill a non-redundant role in the adaptive immune system. Because their functions overlap, it is likely that [gamma delta] T cells are distinctive from [alpha beta] T cells in the way they are triggered by antigen. These antigenic triggers of [gamma delta] T cells remain poorly defined, but a more thorough knowledge of this repertoire will enhance understanding of the role of [gamma delta] T cells in the immune response. The identification of new [gamma delta] T cell antigens was undertaken, resulting in the discovery of hapten small molecule [gamma delta] T cell ligands and the identification of a diverse group of additional candidate [gamma delta] T cell ligands. With the discovery that [gamma delta] T cell receptors can recognize small molecules in addition to their known large protein ligands, it is clear that [gamma delta] T cells fill a unique role in the adaptive immune system is solidified with a broad capacity for antigen recognition along with all the functionality of T cells, and are uniquely situated to function together with [alpha beta] T cells and B cells in a concerted antigen-specific response.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2012 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Meyer, Christina | |
|---|---|---|
| Associated with | Stanford University, Program in Immunology. | |
| Primary advisor | Chien, Yueh-Hsiu | |
| Thesis advisor | Chien, Yueh-Hsiu | |
| Thesis advisor | Davis, Mark M | |
| Thesis advisor | Garcia, K. Christopher | |
| Thesis advisor | Monack, Denise M | |
| Advisor | Davis, Mark M | |
| Advisor | Garcia, K. Christopher | |
| Advisor | Monack, Denise M |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Christina Meyer. |
|---|---|
| Note | Submitted to the Program in Immunology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Christina Meyer
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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