Visual motion generates predictive inhibition in the retina
Abstract/Contents
- Abstract
- Prediction is a central function of the nervous system with few known mechanisms. Retinal motion anticipation is one example, whereby ganglion cells predictively shift their activity in the direction of motion. I directly measured how salamander amacrine cells contribute to motion processing using simultaneous intracellular and multielectrode recording. By dynamically manipulating the gain of single amacrine cells, I found that inhibition itself anticipates motion, shifting predictively such that inhibition matches excitation of the target ganglion cells. Consequently, sustained amacrine cells control the response gain of nonlinear ganglion cells during motion. This finding strongly deviates from effects predicted by measuring amacrine transmission during other stimulus types, showing the critical need to match perturbations to specific stimuli in order to correctly interpret neural function. A computational model indicates that fast release and depletion of synaptic vesicles could underlie the predictive shift of inhibition, suggesting a general simple mechanism for prediction of changing stimuli.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Lee, Dongsoo |
|---|---|
| Degree supervisor | Baccus, Stephen A |
| Thesis advisor | Baccus, Stephen A |
| Thesis advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Thesis advisor | Huberman, Andrew |
| Thesis advisor | Raymond, Jennifer L |
| Degree committee member | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Degree committee member | Huberman, Andrew |
| Degree committee member | Raymond, Jennifer L |
| Associated with | Stanford University, Neurosciences Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Dongsoo Lee. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/fk602nm9253 |
Access conditions
- Copyright
- © 2022 by Dongsoo Lee
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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