Germline-Targeting HIV-1 Immunogen Design

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Abstract/Contents

Abstract: Human immunodeficiency virus type 1 (HIV-1) has caused one of the worst pandemics in human history. Although treatments can slow the progression of HIV-1, no cure exists and infected patients must live with the virus for life. Moreover, HIV-1 continues to spread rapidly in certain regions of the world, making vaccine development a global health priority. Because of HIV-1's high antigenic diversity, an effective vaccine must be able to elicit broadly-neutralizing antibodies (bnAbs). BnAbs against the CD4 binding site of the HIV envelope glycoprotein 120 (gp120) have been isolated from rare HIV-infected individuals, but attempts to elicit such bnAbs through vaccination have failed. This lack of bnAb induction is largely due to viral features that obstruct germline (gl) antibody binding and thereby prevent maturation into high-affinity bnAbs. Guided by computational modeling, we engineered a germline-targeting immunogen based on gp120's outer domain. This construct is able to bind multiple mature bnAbs with high affinity in addition to a predicted germline precursor, making it a strong vaccine candidate.

Type of resource	text
Date created	May 14, 2018

Author	Naidu, Anika Srinivas
Degree granting institution	Stanford University, Department of Bioengineering
Primary advisor	Huang, Possu
Advisor	Kim, Peter S.

Subject	HIV
Subject	Immunogen
Subject	Vaccine
Subject	gp120
Subject	Rational Design
Subject	Stanford School of Engineering
Subject	Department of Bioengineering
Genre	Thesis

Location	https://purl.stanford.edu/fj454sc9413

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License: This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

Preferred Citation: Naidu, Anika Srinivas. (2018). Germline-Targeting HIV-1 Immunogen Design. Stanford Digital Repository. Available at: https://purl.stanford.edu/fj454sc9413

Undergraduate Theses, School of Engineering

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